Meaningful Change in Mental Health Treatment with the Reliable Change Index and Minimally Important Difference

Meaningful Change in Mental Health Treatment with the Reliable Change Index and Minimally Important Difference

Highlights:

  • Psychometric science provides evidence for your client’s improvement or deterioration.
  • The Reliable Change Index (RCI) and Minimally Important Difference (MID) can help you determine if client change is meaningful.
  • NovoPsych uses various data-driven methods to provide nuanced interpretations for change scores.

Trusting your intuition can be empowering, but like a tightrope walker needing a safety net, it thrives with the support of evidence. How strong is your trust in intuition when it comes to assessing progress or deterioration in your clients? A meta-analysis by Miller et al. (2015) suggests that clinical decisions regarding client improvements based solely on intuition are not as accurate as those based on psychometric assessments.

Intuition can be enhanced by the rigour and precision of statistical analysis, potentially picking up important trends. Relying solely on intuition can overlook blind spots and hinder symptom reduction, especially for clients who initially do not show improvement (Lambert et al., 2003). Measurement-based care in psychotherapy, which involves the regular administration of standardised assessments, complements clinical intuition and is increasingly recognised as essential (Meyer et al., 2001).  At NovoPsych, we strive to accurately assess changes—improvement or deterioration— in a client’s mental health by integrating various empirical methods and providing clinicians with a solid sense of clinically meaningful change.

Measuring Change- Not So Simple

A rudimentary and sometimes misleading method to determine change scores is to review the severity descriptors to quantify whether an individual has changed severity category. We know from experience that many clinicians use this method. For example, the Depression Anxiety and Stress Scale (DASS-21) manual delineates distinct categories such as “mild,” “moderate,” “severe,” and “extremely severe” (see Figure 1) (Lovibond & Lovibond, 1995). Some clinicians then simply determine if a client has improved (or worsened) by assessing if the client has moved to a different severity classification category. For example, we could determine that a client has improved if they were ‘Severe’ when they first started seeing us but they are now classified as ‘Moderate’.

Figure 1. DASS-21 severity classification table showing score ranges for total and subscale measures across five categories.

However, a crucial issue with these severity descriptors is that some of the defined ranges are quite broad, which hinders the systematic tracking of improvement and deterioration within these categories. Conversely, a client could demonstrate minimal change and improve by only 1 point but change from one severity classification to another. These are crucial limitations. Therefore, a method for determining meaningful score changes instead of focussing upon severity descriptor changes is required.

Reliable Change Index (RCI)

One such method is the Reliable Change Index (RCI), which assesses whether changes in an individual’s psychological scale scores before and after treatment are statistically significant, adjusting for natural fluctuations, to determine genuine improvement or deterioration (Jacobson et al., 1984). RCI is a rigorous and empirical standard to assess change, and is often described as the gold standard.

NovoPsych exemplified the effective use of the RCI by analysing over 90,000 DASS-21 assessments to determine the level of change needed to be considered “Reliable Change” and included this information in our reports to enhance the interpretation for clinicians. We calculated RCIs using the Jacobson-Truax method and internal reliabilities (Jacobson & Truax, 1991) in order to categorise change with meaningful descriptors, such as significant improvements (i.e., a reduction in over DASS-21 score of 7 or more points), aiding clinicians in evaluating treatment effectiveness. These cut-offs for improvement (or deterioration), are based upon differences between initial and most recent scores and provide clear benchmarks for assessing psychological well-being.

NovoPsych’s outcome data analysis package called Insights, uses the RCI to determine the proportion of clients that have changed. In this way, a practice can determine in a statistically rigorous way the change in a group of client symptoms pre and post treatment.

The figure below shows that for a typical practice, 54.8% of clients have significant improvement in DASS-21 scores, based on the RCI (see Figure 2).

Figure 2. Client Outcomes Using Reliable Change Index (RCI)

This highlights that a large proportion of people (36.3%) are considered to have no significant change, as determined by the RCI threshold of 7 points. Significant improvement was achieved by 54.8% of clients at this practice. On the other hand, if using a simplistic valuation of change being determined by just one point change on the DASS-21, the same data shows 75.1% improvement (Figure 3). This highlights how different methods of calculating change at a group level can impact overall interpretation.

Figure 3. Client Outcomes Using One-Point Change Criterion

By adding this to NovoPsych’s interpretations, we save clinicians from needing to learn about the actual maths behind RCI (Formula 1):

Formula 1. The Jacobson-Truax method of clinical significance classification (Jacobson & Truax, 1991). Note. xpre= pre-test score of clients; xpost = post-test score of clients; s1 = standard deviation of the pre-treatment group; rxx = internal reliability of the scale (as per Bauer et al., 2004).

Example 1. Consider the case of a hypothetical client whose score on the DASS-21 has decreased from 59 to 40 (see Figure 4). Despite both the initial and new total scores falling within the “Extremely Severe” range, there was clinically significant improvement of 19 points. Although this improvement is clearly evident in the NovoPsych plot of scores over time (Figure 4), if a clinician was only looking at the severity descriptor, it would appear that the client has not improved. In addition to the plot, NovoPsych will highlight in the Interpretive Text (see Figure 5) that this client has improved significantly on their overall distress.

Figure 4. Line graph visualising DASS-21 score decrease from 59 to 40 over time.

By utilising this calculation approach, grounded in robust statistical models, we offer clinicians more detailed insights into changes in mental health.

Figure 5. NovoPsych’s Interpretive Text highlighting significant improvement despite unchanged severity category.

Example 2. Despite minimal score changes, the graph in Figure 6 demonstrates that severity descriptors can shift due to predefined cut-off thresholds. NovoPsych’s advanced statistical methods ensure that slight score variations, despite a change in descriptor, are accurately recognised in the Interpretive text as indicating no significant change (see Figure 7).

Figure 6. Graph demonstrating how small score changes can shift severity descriptors due to cut-off thresholds.

Figure 7. NovoPsych’s interpretation accurately identifying no significant change despite descriptor shift.

Effective evaluation of treatment outcomes hinges on clear and standardised classifications that guide clinicians in assessing client progress. NovoPsych integrates these classifications seamlessly into tools like the DASS-21, leveraging the RCI to establish thresholds for meaningful changes.

The Minimally Important Difference (MID)

An RCI is not always available either because research has not determined it or because there might not be enough NovoPsych data to calculate it (if we are adding a new assessment). Therefore, an alternative to the RCI could be beneficial for clinicians.

While several alternatives to RCI exist for outcome monitoring, the Minimally Important Difference (MID) stands out as a simple yet empirically sound method (Turner et al., 2010). MID represents the smallest change in a treatment outcome that clients perceive as beneficial or clinically meaningful. According to a review by Norman et al. (2003), which examined 38 studies across various conditions and instruments, changes approaching half a standard deviation (about 0.5 SD) consistently signalled meaningful change. Their research underscores the reliability and relevance of MID in clinical settings, advocating for its widespread adoption.

Using the MID to track mental health outcomes offers several advantages. Firstly, MID establishes a definitive threshold for meaningful change using the mean and variance of a representative sample, eliminating the need for research to longitudinally track outcomes to produce an RCI. Secondly, it enhances sensitivity, allowing detection of subtle yet important changes in client status (Toussaint et al., 2020). Finally, MID promotes a client-centred approach by aligning treatment goals with changes that are perceptible and meaningful to clients, improving engagement and satisfaction (Jayadevappa et al., 2017).

Example 3. NovoPsych utilises the MID to assess score changes in the Oldenburg Burnout Inventory. This approach ensures that even when clients remain within the same severity category (e.g., “High Burnout,” as shown in Figure 8), the interpretation highlights meaningful shifts in their scores (see Figure 9). It provides clinicians with a precise assessment of client progress that extends beyond conventional severity descriptors.

Figure 8. Oldenburg Burnout Inventory scores chart, showing change within “High Burnout” category

Figure 9. NovoPsych’s interpretation of Burnout scores, highlighting meaningful shifts using the MID approach.

Psychometric science, exemplified by methods such as the Reliable Change Index (RCI) and Minimally Important Difference (MID), plays an important role in interpreting client change in mental health treatment. The RCI and MID are NovoPsych preferred methods for determining change thresholds and are used on many assessments designed for outcome monitoring. The RCI is a more stringent and conservative metric for change compared with the MID, whereby the RCI will show fewer clients have changed compared to the MID. For example, NovoPsych data shows that based on the DASS-21 RCI, 49% of clients in therapy have significant improvement on Total Distress, but using the MID on the same data shows 56% of clients improved. Put another way, the RCI requires a 7-point difference to be classified as meaningful improvement, whereas the MID requires only a 5-point difference.

NovoPsych builds these rigorous statistical methods into our assessment interpretation so clinicians can combine it with their knowledge of their patient’s treatment journey to help paint a picture of recovery based on statistics and clinician intuition. NovoPsych supports clinicians in making informed decisions that enhance the effectiveness and personalisation of client care. This approach strengthens assessment reliability and emphasises measurable and meaningful changes in mental health outcomes.

References

Bauer, S., Lambert, M. J., & Nielsen, S. L. (2004). Clinical Significance Methods: A Comparison of Statistical Techniques. Journal of Personality Assessment, 82(1), 60–70. https://doi.org/10.1207/s15327752jpa8201_11
 

Jacobson, N. S., & Truax, P. (1991). Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59(1), 12–19. https://doi.org/10.1037/0022-006X.59.1.12

Jacobson, N. S., Follette, W. C., & Revenstorf, D. (1984). Psychotherapy outcome research: Methods for reporting variability and evaluating clinical significance. Behavior Therapy, 15(4), 336–352. https://doi.org/10.1016/S0005-7894(84)80002-7

Jayadevappa, R., Cook, R., & Chhatre, S. (2017). Minimal important difference to infer changes in health-related quality of life—a systematic review. Journal of Clinical Epidemiology, 89, 188–198. https://doi.org/10.1016/j.jclinepi.2017.06.009

Lambert, M. J., Whipple, J. L., Hawkins, E. J., Vermeersch, D. A., Nielsen, S. L., & Smart, D. W. (2003). Is it time for clinicians to routinely track patient outcome? A meta-analysis. Clinical Psychology (New York, N.Y.), 10(3), 288–301. https://doi.org/10.1093/clipsy.bpg025

Lovibond, S.H. & Lovibond, P.F. (1995). Manual for the Depression Anxiety Stress Scales (2nd ed.). Sydney: Psychology Foundation (Available from The Psychology Foundation, Room 1005 Mathews Building, University of New South Wales, NSW 2052, Australia.

Meyer, G. J., Finn, S. E., Eyde, L. D., Kay, G. G., Moreland, K. L., Dies, R. R., Eisman, E. J., Kubiszyn, T. W., & Reed, G. M. (2001). Psychological testing and psychological assessment: A review of evidence and issues. The American Psychologist, 56(2), 128–165. https://doi.org/10.1037/0003-066X.56.2.128

Miller, D. J., Spengler, E. S., & Spengler, P. M. (2015). A meta-analysis of confidence and judgment accuracy in clinical decision making. Journal of Counseling Psychology, 62(4), 553–567. https://doi.org/10.1037/cou0000105

Norman, G. R., Sloan, J. A., & Wyrwich, K. W. (2003). Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation. Medical Care, 41(5), 582–592. https://doi.org/10.1097/01.MLR.0000062554.74615.4C

Toussaint, A., Hüsing, P., Gumz, A., Wingenfeld, K., Härter, M., Schramm, E., & Löwe, B. (2020). Sensitivity to change and minimal clinically important difference of the 7-item Generalised Anxiety Disorder Questionnaire (GAD-7). Journal of Affective Disorders, 265, 395–401. https://doi.org/10.1016/j.jad.2020.01.032

Turner, D., Schünemann, H. J., Griffith, L. E., Beaton, D. E., Griffiths, A. M., Critch, J. N., & Guyatt, G. H. (2010). The minimal detectable change cannot reliably replace the minimal important difference. Journal of Clinical Epidemiology, 63(1), 28–36. https://doi.org/10.1016/j.jclinepi.2009.01.024

Eating Disorder-15 (ED-15)

Dr Mandira Mishra

The Eating Disorder-15 is a 15-item scale to measure session-by-session change for eating disorder attitudes and behaviours. The scale measures the frequency of eating-disordered behaviours and has two factors:

  • Weight & Shape Concerns
  • Eating Concerns

Developer

Tatham, M., Turner, H., Mountford, V. A., Tritt, A., Dyas, R., & Waller, G. (2015). Development, psychometric properties and preliminary clinical validation of a brief, session-by-session measure of eating disorder cognitions and behaviors: The ED-15. The International Journal of Eating Disorders, 48(7), 1005–1015. https://doi.org/10.1002/eat.22430

References

University of Sheffield resources for cognitive behavioural therapy in ten sessions for patients with non-underweight eating disorders.  https://cbt-t.sites.sheffield.ac.uk/resources

Accurso, E. C., & Waller, G. (2021). A brief session-by-session measure of eating disorder psychopathology for children and adolescents: Development and psychometric properties of the Eating Disorder-15 for Youth (ED-15-Y). The International journal of eating disorders, 54(4), 569–577. https://doi.org/10.1002/eat.23449

Accurso, E. C., & Waller, G. (2021). Concordance between youth and caregiver report of eating disorder psychopathology: Development and psychometric properties of the Eating Disorder‐15 for Parents/Caregivers (ED‐15‐P). International Journal of Eating Disorders, 54(7), 1302-1306. https://doi.org/10.1002/eat.23557
 
Murray, S. B., Levinson, C. A., Farrell, N. R., Nagata, J. M., Compte, E. J., & Le Grange, D. (2020). The open versus blind weight conundrum: A multisite randomised controlled trial across multiple levels of patient care for anorexia nervosa. The International journal of eating disorders, 53(12), 2079–2085. https://doi.org/10.1002/eat.23397
 
Pellizzer, M. L., Waller, G., & Wade, T. D. (2019). A pragmatic effectiveness study of 10‐session cognitive behavioural therapy (CBT‐T) for eating disorders: Targeting barriers to treatment provision. European Eating Disorders Review, 27(5), 557-570. https://doi.org/10.1002/erv.2684
 
Rodrigues, T., Vaz, A. R., Silva, C., Conceição, E., & Machado, P. P. P. (2019). Eating Disorder-15 (ED-15): Factor structure, psychometric properties, and clinical validation. European Eating Disorders Review: The Journal of the Eating Disorders Association, 27(6), 682–691. https://doi.org/10.1002/erv.2694
 
Tatham, M., Turner, H., Mountford, V. A., Tritt, A., Dyas, R., & Waller, G. (2015). Development, psychometric properties and preliminary clinical validation of a brief, session-by-session measure of eating disorder cognitions and behaviors: The ED-15. The International Journal of Eating Disorders, 48(7), 1005–1015. https://doi.org/10.1002/eat.22430
 
Yilmaz, H. Ö., Polat, A., Köse, G., Balci, S., & Günal, A. M. (2023). Eating Disorder-15: Factor Structure, Psychometric Properties, Validity, and Reliability of the Turkish Version for Clinical and Non-Clinical Samples. Turkish journal of psychiatry, 34(1), 31–38. https://pubmed.ncbi.nlm.nih.gov/36970960/

Male Depression Risk Scale (MDRS-22)

Dr Mandira Mishra

The 22-item Male Depression Risk Scale (MDRS-22) is a self-report instrument that can be used to identify adult men’s risk of depression, with a focus on externalising signs and symptoms (i.e., aggression & drug use; Rice et al., 2013). The MDRS-22 has a particular advantage over gender-neutral depression rating scales, as it specially measures factors empirically associated with depression and suicidality in men and emphasises maladaptive coping strategies. 

 

Developer

Rice, S. M., Fallon, B. J., Aucote, H. M., Möller-Leimkühler, A., Treeby, M. S., & Amminger, G. P. (2015). Longitudinal sex differences of externalising and internalising depression symptom trajectories: Implications for assessment of depression in men from an online study. The International Journal of Social Psychiatry, 61(3), 236–240. https://doi.org/10.1177/0020764014540149

References

Rice, S. M., Fallon, B. J., Aucote, H. M., & Möller-Leimkühler, A. M. (2013). Development and preliminary validation of the male depression risk scale: Furthering the assessment of depression in men. Journal of Affective Disorders, 151(3), 950-958. https://doi.org/10.1016/j.jad.2013.08.013

Herreen, D., Rice, S., Ward, L., & Zajac, I. (2022). Extending the Male Depression Risk Scale for use with older men: the effect of age on factor structure and associations with psychological distress and history of depression. Aging & Mental Health, 26(8), 1524–1532. https://doi.org/10.1080/13607863.2021.1947966

Rice, S. M., Ogrodniczuk, J. S., Kealy, D., Seidler, Z. E., Dhillon, H. M., & Oliffe, J. L. (2019). Validity of the Male Depression Risk Scale in a representative Canadian sample: sensitivity and specificity in identifying men with recent suicide attempt. Journal of Mental Health, 28(2), 132–140. doi: 10.1080/09638237.2017.1417565

Rice, S. M., Kealy, D., Seidler, Z. E., Oliffe, J. L., Levant, R. F., & Ogrodniczuk, J. S. (2020). Male-Type and Prototypal Depression Trajectories for Men Experiencing Mental Health Problems. International Journal of Environmental Research and Public Health, 17(19), 7322. https://doi.org/10.3390/ijerph17197322

Walther, A., Grub, J., Ehlert, U., Wehrli, S., Rice, S., Seidler, Z. E., & Debelak, R. (2021). Male depression risk, psychological distress, and psychotherapy uptake: Validation of the German version of the male depression risk scale. Journal of Affective Disorders Reports, 4, 100107. https://doi.org/10.1016/j.jadr.2021.100107

Life Events Checklist for DSM-5 (LEC-5)

Dr Mandira Mishra

The Life Events Checklist for DSM-5 (LEC-5) is a self-report tool developed by the National Center for Post-traumatic Stress Disorder (PTSD) to measure exposure to potentially traumatic events and assist with the diagnosis of PTSD. The LEC-5 contains 17 questions inquiring about the experiences of potentially traumatic events associated with post-traumatic difficulties in adults (18+ years). The LEC-5 is used to establish exposure to a PTSD Criterion A traumatic event and is subsequently used in combination with other measures (e.g. PTSD Checklist for DSM-5 (PCL-5)) to establish if other diagnostic criteria are present (Weathers et al., 2013).

 

Developer

Weathers, F.W., Blake, D.D., Schnurr, P.P., Kaloupek, D.G., Marx, B.P., & Keane, T.M. (2013). The Life Events Checklist for DSM-5 (LEC-5). Instrument available from the National Center for PTSD at www.ptsd.va.gov

References

Contractor, A. A., Weiss, N. H., Natesan Batley, P., & Elhai, J. D. (2020). Clusters of Trauma Types as Measured by the Life Events Checklist for DSM-5. International Journal of Stress Management, 27(4), 380–393. https://doi.org/10.1037/str0000179

Gray, M. J., Litz, B. T., Hsu, J. L., & Lombardo, T. W. (2004). Psychometric Properties of the Life Events Checklist. Assessment (Odessa, Fla.), 11(4), 330–341. https://doi.org/10.1177/1073191104269954

Pugach, C. P., Nomamiukor, F. O., Gay, N. G., & Wisco, B. E. (2021). Temporal Stability of Self‐Reported Trauma Exposure on the Life Events Checklist for DSM‐5. Journal of Traumatic Stress, 34(1), 248–256. https://doi.org/10.1002/jts.22611

Weathers, F.W., Blake, D.D., Schnurr, P.P., Kaloupek, D.G., Marx, B.P., & Keane, T.M. (2013). The Life Events Checklist for DSM-5 (LEC-5). Instrument available from the National Center for PTSD at www.ptsd.va.gov

Montgomery-Asberg Rating Scale (MADRS)

Dr Mandira Mishra

The Montgomery-Asberg Rating Scale (MADRS) is a 10-item clinician-rated assessment for depression in adults (18+). The MADRS focusses more upon functional impairment and somatic symptoms than other assessments which might focus more upon depressive cognitive attitudes (Montgomery and Asberg, 1979). 

 

Developer

Montgomery, S.A., & Asberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134(4), 382–389. doi: 10.1192/bjp.134.4.382. PMID: 444788.

References

Carmody, T.J., Rush, A.J., Bernstein, I., Warden, D., Brannan, S., Burnham, D., et al. (2006). The Montgomery Äsberg and the Hamilton ratings of depression: a comparison of measures. European Journal of Neuropsychopharmacology, 16(8), 601–611. doi: 10.1016/j.euroneuro.2006.04.008. Epub 2006 Jun 12. PMID: 16769204; PMCID: PMC2151980.

Davidson, J., Turnbull, C.D., Strickland, R., Miller, R., & Graves, K. (1986). The Montgomery-Asberg Depression Scale: reliability and validity. Acta Psychiatry Scandinavica, 73(5), 544–548. doi: 10.1111/j.1600-0447.1986.tb02723.x. PMID: 3751660.

Fredriksen, K. J., Gjestad, R., Walby, F. A., Anda, L. G., Oedegaard, K. J., & Schoeyen, H. K. (2022). High Scores on the Montgomery-Åsberg Depression Rating Scale and Psychotic Symptoms Predict Suicide: A Prospective Cohort Study of Psychiatric Acute Ward Patients. The Journal of Clinical Psychiatry, 83(5), 41950. https://doi.org/10.4088/JCP.21m14018

Heo, M., Murphy, C.F., & Meyers, B.S. (2007). Relationship between the Hamilton Depression Rating Scale and the Montgomery-Åsberg Depression Rating Scale in depressed elderly: a meta-analysis. American Journal of Geriatric Psychiatry, 15(10), 899–905. doi: 10.1097/JGP.0b013e318098614e. PMID: 17911366.

Mulder, R.T., Joyce, P.R., & Frampton, C. (2003). Relationships among measures of treatment outcome in depressed patients. Journal of Affective Disorders, (1–3), 127–135. doi: 10.1016/s0165-0327(02)00080-0. PMID: 12943942.

Müller, M. J., Himmerich, H., Kienzle, B., & Szegedi, A. (2003). Differentiating moderate and severe depression using the Montgomery-Asberg depression rating scale (MADRS). Journal of Affective Disorders, 77(3), 255–260. https://doi.org/10.1016/s0165-0327(02)00120-9

Snaith, R., Harrop, F., Newby, D., & Teale, C. (1986). Grade Scores of the Montgomery—Åsberg Depression and the Clinical Anxiety Scales. British Journal of Psychiatry, 148(5), 599-601. doi:10.1192/bjp.148.5.599

Fredriksen, K. J., Gjestad, R., Walby, F. A., Anda, L. G., Oedegaard, K. J., & Schoeyen, H. K. (2022). High Scores on the Montgomery-Åsberg Depression Rating Scale and Psychotic Symptoms Predict Suicide: A Prospective Cohort Study of Psychiatric Acute Ward Patients. The Journal of Clinical Psychiatry, 83(5), 41950. https://doi.org/10.4088/JCP.21m14018

Thase, M. E., Harrington, A., Calabrese, J., Montgomery, S., Niu, X., & Patel, M. D. (2021). Evaluation of MADRS severity thresholds in patients with bipolar depression. Journal of Affective Disorders, 286, 58–63. https://doi.org/10.1016/j.jad.2021.02.043

Turkoz, I., Alphs, L., Singh, J., Jamieson, C., Daly, E., Shawi, M., Sheehan, J. J., Trivedi, M. H., & Rush, A. J. (2021). Clinically meaningful changes on depressive symptom measures and patient-reported outcomes in patients with treatment-resistant depression. Acta Psychiatrica Scandinavica, 143(3), 253–263. https://doi.org/10.1111/acps.13260